DOCTOR'S Profile
ABOUT Dr. Ram Krishna Chandyo
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He has completed MBBS (MD) in 1997 at Saint-Petersburg Pediatric Medical Academy, Russia. He has done MPhil in Child Health and Nutrition at University of Bergen, Centre for International Health, Norway. Dr. Chandyo completed his PhD on “Zinc, iron and infection-studies in children and women in Nepal” from the University of Bergen, Norway in 2011. Currently, he is an Associate Professor at the Department of Community medicine.

His initial research studies mainly focused on impact of micronutrient status on common infection such as diarrhea and pneumonia among children in Bhaktapur. He was a co-investigator for a large community based clinical trial on zinc for acute diarrhea and results from this study contributed for WHO recommendation of zinc for the treatment of diarrhea in children. He was also one of the field investigators for a multi-country cohort study on malnutrition and enteric disease (MAL-ED) funded by Gates Foundation and community based COPD screening study (Global Excellence on COPD Outcomes) with support from University College of London.

Currently, Dr Chandyo’ s studies are focusing on impact of vitamin B12 supplementation for pregnant women and infant on growth and cognitive development. Recently, his team have complemented vitamin B12 supplementation clinical trial where 600 marginally stunted infants were given vitamin B12 for one year period and assessed growth and cognitive development which was funded by Thrasher Research Fund. With the joint collaboration with University of Bergen, Norway, a large clinical trial on vitamin B12 is currently ongoing where 800 pregnant mothers in first trimester are participating and outcomes on child’s growth and cognitive development will be measured at 1 and 2 years of age.

Dr. Ram Krishna Chandyo
MD, MPhil, PhD
Associate Professor
NMC Number
2438
Specialization

Child Health and Nutritional Research

MBBS (MD) in 1997

at Saint-Petersburg Pediatric Medical Academy, Russia

MPhil in Child Health and Nutrition

at University of Bergen, Centre for International Health, Norway

Publications

 

  1. Tor A Strand, Ram K Chandyo, Rajiv Bahl, Puspa R Sharma, Ramesh K Adhiakari, Nita Bhandari, Rune J Ulvik et al.- Effectiveness and Efficacy of Zinc for the treatment of Acute Diarrhea in Young Children- Pediatrics Vol.109 No.5 May 2002.
  2. Strand TA, Adhikari, RK, Chandyo, RK, Sharma PR, and Sommerfelt H. Determinants of plasma zinc levels in children with acute diarrhea. Am J Clin Nutr. 2004:79:451-6
  3. Chandyo, RK, Strand, TA. Zinc for Child Health – Implications of research findings – Journal of Nepal Medical Association, 2004
  4. Palle Valentiner-Branth,, Prakash S. Shrestha,  Ram K. Chandyo, Maria Mathisen , Sudha Basnet, Nita Bhandari et al. "A randomized controlled trial of the effect of zinc as adjuvant therapy in children 2-35 mo of age with severe or nonsevere pneumonia in Bhaktapur, Nepal." The American journal of clinical nutrition 91(6): 1667-1674”
  5. Ram K. Chandyo, Prakash S. Shrestha, Palle Valentiner-Branth, Maria Mathisen, et al. Two weeks of zinc administration to Nepalese children with pneumonia does not reduce the incidence of pneumonia or diarrhea during the next six months." The Journal of nutrition 140(9): 1677-1682”
  6. Chandyo, RK, Strand TA, Ulvik RJ, Adhikari, RK, , Ulak, M, Dixit, H, and Sommerfelt H. Prevalence of Iron Deficiency and Anemia among Healthy Women of Reproductive age in Bhaktapur, Nepal, European Journal of Clinical Nutrition, 2007 Feb;61:262-9
  7. Chandyo, RK, Strand TA, Mathisen, M, Ulak, M, Adhikari, R, Bjørn J Bolann and Sommerfelt H. Zinc Deficiency is Common among Healthy Women of Reproductive age in Bhaktapur, Nepal. Journal of Nutrition. 139: 594-597, 2009
  8. Henjum S, Manger M, Skeie E, Ulak M, Thorne-Lyman AL, Chandyo R, et al. "Iron deficiency is uncommon among lactating women in urban Nepal, despite a high risk of inadequate dietary iron intake". Br J Nutr. 2014 Jul 14;112(1):132-41
  9. Henjum S, Torheim LE, Thorne-Lyman AL, Chandyo R, Fawzi  WW, Shrestha PS, Strand TA. Low dietary diversity and micronutrient adequacy among lactating women in a peri-urban area of Nepal. Public Health Nutrition, 2015 Mar 31.
  10. Ram K Chandyo, Manjeswori Ulak, Ramesh K Adhikari, Halvor sommerfelt, Tor A Strand, “Prevalence of Iron deficiency and Anemia among young children with acute diarrhea in Bhaktapur, Nepal”. Healthcare 2015, 3, 593-606.
  11. Chandyo RK, Ulak M, Sommerfelt H, Schneede J, Ueland PM, Strand TA. Nutritional Intake and Status of Cobalamin and Folate among Non-Pregnant Women of Reproductive Age in Bhaktapur, Nepal. Nutrients. 2016 Jun 22;8(6
  12. Henjum S, Kjellevold M, Ulak M, Chandyo RK, Shrestha PS, Frøyland L, Strydom EE, Dhansay MA, Strand TA. Iodine Concentration in Breastmilk and Urine among Lactating Women of Bhaktapur, Nepal. Nutrients. 2016 Apr 28;8(5)
  13. Chandyo RK, Henjum S, Ulak M, Thorne-Lyman AL, Ulvik RJ, Shrestha PS, Locks L, Fawzi W, Strand TA. The prevalence of anemia and iron deficiency is more common in breastfed infants than their mothers in Bhaktapur, Nepal. Eur J Clin Nutr. 2016 Apr;70(4):456-62
  14. Ulak M, Chandyo RK, Thorne-Lyman AL, et al .Vitamin Status among Breastfed Infants in Bhaktapur, Nepal. Nutrients. 2016 Mar 8;8(3)
  15. Mitchell NJ, Hsu HH, Chandyo RK, Shrestha B, Bodhidatta L, Tu YK, Gong YY, Egner PA, Ulak M, Groopman JD, Wu F. “Aflatoxin exposure during the first 36 months of life was not associated with impaired growth in Nepalese children: An extension of the MAL-ED study.”  PLoS One. 2017 Feb 17;12(2)
  16. Henjum S, Lie Ø, Ulak M, Thorne-Lyman AL, Chandyo RK, Shrestha PS, W Fawzi W, Strand TA, Kjellevold M. “Erythrocyte fatty acid composition of Nepal breast-fed infants.” Eur J Nutr. 2017 Feb 25
  17. Mitchell NJ, Hsu HH, Chandyo RK, Shrestha B, Bodhidatta L, Tu YK, Gong YY, Egner PA, Ulak M, Groopman JD, Wu F. “Aflatoxin exposure during the first 36 months of life was not associated with impaired growth in Nepalese children: An extension of the MAL-ED study.”  PLoS One. 2017 Feb 17;12(2)
  18. Poudel-Tandukar K, Chandyo RK. “Dietary B Vitamins and Serum C-Reactive Protein in Persons With Human Immunodeficiency Virus Infection: The Positive Living With HIV (POLH) Study.” Food Nutr Bull. 2016 Dec;37(4):517-528.
  19. Maria Mathisen, Tor A. Strand, Biswa N. Sharma, Ram K. Chandyo, et al. "Clinical presentation and severity of viral community-acquired pneumonia in young Nepalese children." The Pediatric Infectious Disease Journal 29(1): e1-6”
  20. Lee GO, Richard SA, Kang G, Houpt ER, Seidman JC, Pendergast LL, Bhutta ZA, Ahmed T, Mduma ER, Lima AA, Bessong P, Jennifer MS, Hossain MI, Chandyo RK, et al. MAL-ED Network Investigators. A Comparison of Diarrheal Severity Scores in the MAL-ED Multisite Community Based Cohort Study. J Pediatr Gastroenterol Nutr. 2016 Jun 2
  21. Maria Mathisen, Tor A. Strand, Palle Valentiner-Branth, Ram K. Chandyo, Sudha Basnet, et al. "Respiratory viruses in Nepalese children with and without pneumonia: a case-control study." The Pediatric Infectious Disease Journal 29(8): 731-735”
  22. Strand TA, Sharma PR, Gjessing HK, Ulak M, Chandyo RK, Adhikari RK, Sommerfelt H. “Risk factors for extended duration of acute diarrhea in young children”. PLoS One. 2012;7(5):e36436
  23. Bates MN, Pokhrel AK, Chandyo RK, Valentiner-Branth P, Mathisen M, Basnet S, Strand TA, Burnett RT, Smith KR. “Kitchen PM2.5 concentrations and child acute lower respiratory infection in Bhaktapur, Nepal: The importance of fuel type”. Environ Res. 2018 Feb;161:546-553
  24. Pokhrel AK, Bates MN, Acharya, J, Valentiner-Branth P, Chandyo RK, Shrestha PS, Raut, A,Smith KR. "PM 2.5 in household kitchens of Bhaktapur, Nepal using four different cooking fuels”. Atmospheric Environment 113 (2015). 159-168.
  25. Crystal L. Patil, Ali Turab, Ramya Ambikapathi, Cebisa Nesamvuni, Ram Krishna Chandyo, Anuradha Bose, et al. on behalf of the MAL-ED network. "Early interruption of exclusive breastfeeding: results from the eight-country MAL-ED study. Journal of Health Population Nutrition, 2015, 34;10.
  26. Schwinger C, Fadnes LT, Shrestha SK, Shrestha PS, Chandyo RK, Shrestha B et al. Predicting Undernutrition at Age 2 Years with Early Attained Weight and Length Compared with Weight and Length Velocity. J Pediatr. 2017 Mar;182:127-132.e1
  27. Richard SA, McCormick BJJ, Seidman JC, Rasmussen Z, Kosek MN, Rogawski ET, Petri W, Bose A, Mduma E, Maciel BLL, Chandyo RK, Bhutta Z et al. “Relationships among Common Illness Symptoms and the Protective Effect of Breastfeeding in Early Childhood in MAL-ED: An Eight-Country Cohort Study”. Am J Trop Med Hyg. 2018 Jan 29.
  28. Morseth MS, Henjum S, Schwinger C, Strand TA, Shrestha SK, Shrestha B, Chandyo RK, Ulak M, Torheim LE.” Environmental Enteropathy, Micronutrient Adequacy and Length Velocity in Nepalese Children - the Mal-Ed Birth Cohort Study”. J Pediatr Gastroenterol Nutr. 2018 Apr 3
  29. Morseth MS, Strand TA, Torheim LE, Chandyo RK, Ulak M, Shrestha SK, Shrestha B, Henjum S. “Nutrient intake and environmental enteric dysfunction among Nepalese children 9-24 months old-the MAL-ED birth cohort study”. Pediatr Res. 2018 Jul 20.
  30. Ranjitkar S, Kvestad I, Strand TA, Ulak M, Shrestha M, Chandyo RK, Shrestha L, Hysing M. “Acceptability and Reliability of the Bayley Scales of Infant and Toddler Development-III Among Children in Bhaktapur, Nepal”. Front Psychol. 2018 Jul 24;9:1265
  31. Ask TF, Ranjitkar S, Ulak M, Chandyo RK, Hysing M, et al. “The Association Between Heart Rate Variability and Neurocognitive and Socio-Emotional Development in Nepalese Infants.” Front Neurosci. 2019 Apr 26;13:411
  32. Upadhyay RP, Chandyo RK, Kvestad I, Hysing M, Ulak M, Ranjitkar S, Shrestha M, Shrestha L, Strand TA. “Parental height modifies the association between linear growth and neurodevelopment in infancy”. Acta Paediatr. 2019 Oct;108(10):1825-1832
  33. Corrina Moucheraud, Ram K Chandyo et Al. “Engagement in agriculture protects against food insecurity and malnutrition in peri-urban Nepal”. Current Developments in Nutrition, Nov 18
  34. Schwinger C, Fadnes LT, Shrestha SK, Shrestha PS, Chandyo RK, Shrestha B, Ulak M, Bodhidatta L, Mason C, Strand TA. “Predicting Undernutrition at Age 2 Years with Early Attained Weight and Length Compared with Weight and Length Velocity.” J Pediatr. 2017 Mar;182:127-132
  35. Ranjitkar S, Hysing M, Kvestad I, Shrestha M, Ulak M, Shilpakar JS, Sintakala R, Chandyo RK, Shrestha L, Strand TA.. “Determinants of Cognitive Development in the Early Life of Childnren in Bhaktapur, Nepal”. Front Psychol. 2019 Dec 6;10:2739
  36. Kvestad I, Hysing M, Shrestha M, Ulak M, Thorne-Lyman AL, Henjum S, Ueland PM, Midttun Ø, Fawzi W, Chandyo RK, Shrestha PS, Strand TA. “Vitamin B-12 status in infancy is positively associated with development and cognitive functioning 5 y later in Nepalese children.” Am J Clin Nutr. 2017 May;105(5)
  37. Strand TA, Ulak M, Kvestad I, Henjum S, Ulvik A, Shrestha M, Thorne-Lyman AL, Ueland PM, Shrestha PS, Chandyo RK. “Maternal and infant vitamin B12 status during infancy predict linear growth at 5 years”. Pediatr Res. 2018 Jun 4
  38. Henjum S, Kvestad I, Shrestha M, Ulak M, Chandyo RK, Thorne-Lyman AL, Shrestha PS, Kjellevold M, Hysing M, Strand TA. “Erythrocyte DHA and AA in infancy is not associated with developmental status and cognitive functioning five years later in Nepalese children”. Nutr J. 2018 Jul 19;17
  39. Kvestad I, Ranjitkar S, Ulak M, Chandyo RK, Shrestha M, Shrestha L, Strand TA, Hysing M. “Earthquake Exposure and Post-traumatic Stress Among Nepalese Mothers After the 2015 Earthquakes.” Front Psychol. 2019 Apr 2
  40. Chandyo RK, Ulak M, Kvestad I, Shrestha M, Ranjitkar S, Basnet S, Hysing M, Shrestha L, Strand TA. “The effects of vitamin B12 supplementation in pregnancy and postpartum on growth and neurodevelopment in early childhood: Study Protocol for a Randomized Placebo Controlled Trial.” BMJ Open. 2017 Aug 29;7
  41. Strand TA, Ulak M, Chandyo RK, Kvestad I, Hysing M, Shrestha M, Basnet S, Ranjitkar S, Shrestha L, Shrestha PS. “The effect of vitamin B12 supplementation in Nepalese infants on growth and development: study protocol for a randomized controlled trial.” Trials. 2017 Apr 21;18(1)
  42. Ulak M, Ranjitkar S, Shrestha M, Braarud HC, Chandyo RK, Shrestha L, Guedeney A, Strand TA and Kvestad I (2020) “The Feasibility of the Full and Modified Versions of the Alarm Distress Baby Scale (ADBB) and the Prevalence of Social Withdrawal in Infants in Nepal”. Front Psychol. 2020 Aug 26;11:2025
  43. Siddharthan T, Pollard SL, Quaderi SA, Mirelman AJ, Cárdenas MK, Kirenga B, Rykiel NA, Miranda JJ, Shrestha L, Chandyo RK et al. “Effectiveness-implementation of COPD case finding and self-management action plans in low- and middle-income countries: global excellence in COPD outcomes (GECo) study protocol.” Trials. 2018 Oct 19;19(1):571
  44. Arora N, Strand TA, Chandyo RK, Elshorbagy A, Shrestha L, Ueland PM, Ulak M, Schwinger C. “Association of Maternal Plasma Total Cysteine and Growth among Infants in Nepal: A Cohort Study. ”Nutrients. 2020 Sep 17;12(9)
  45. Nicolaou L, Ahmed T, Bhutta ZA, Bessong P, Kosek M, Lima AAM, Shrestha S, Chandyo R et al.
    “Factors associated with head circumference and indices of cognitive development in early childhood.” BMJ Glob Health. 2020 Oct;5(10)
  46. Schwinger C, Chandyo RK, Ulak M, Hysing M, Shrestha M, Ranjitkar S, Strand TA. “
    Prevalence of Underweight, Overweight, and Obesity in Adults in Bhaktapur, Nepal in 2015-2017”.  Front Nutr. 2020 Sep 22;7
  47. Ulak M, Ranjitkar S, Shrestha M, Braarud HC, Chandyo RK, Shrestha L et al. “
    The Feasibility of the Full and Modified Versions of the Alarm Distress Baby Scale (ADBB) and the Prevalence of Social Withdrawal in Infants in Nepal”. Front Psychol. 2020 Aug 26;11
  48. Shrestha M, Schwinger C, Hysing M, Chandyo RK, Ulak M, Ranjitkar S, Kvestad I, Sharma S, Shrestha L and Strand TA (2020) “Agreement Between Mothers and Fieldworkers While Assessing Child Development Using Ages and Stages Questionnaires, Third Edition in Nepal”. Front. Psychol. 11:579412
  49. Tor A. Strand, Manjeswori Ulak, Mari Hysing, Suman Ranjitkar, Ingrid Kvestad, Merina Shrestha, Per M. Ueland, Adrian McCann, Prakash S. Shrestha, Laxman Shrestha, and Ram K. Chandyo. “Effects of vitamin B12 supplementation on neurodevelopment and growth in Nepalese Infants: A randomized controlled trial”. Plos Medicine-1 Dec 2020
  50. Richard SA, McCormick BJJ, Murray-Kolb LE, Lee GO, Seidman JC, Mahfuz M, Ahmed T, Guerrant RL, Petri WA, Rogawski ET, Houpt E, Kang G, Mduma E, Kosek MN, Lima AAM, Shrestha SK, Chandyo RK et. al. “Enteric dysfunction and other factors associated with attained size at 5 years: MAL-ED birth cohort study findings.” Am J Clin Nutr. 2019 Jul 1;110.
  51. Richard SA, McCormick BJJ, Murray-Kolb LE, Patil CL, Chandyo RK, Mahopo C et al. “Characteristics associated with the transition to partial breastfeeding prior to 6 months of age: Data from seven sites in a birth cohort study” Matern Child Nutr. 2021 Mar 4:e13166
  52. Kvestad I, McCann A, Chandyo RK, Giil LM, Shrestha M, Ulak M, Hysing M, Ueland PM, Strand TA. “One-Carbon Metabolism in Nepalese Infant-Mother Pairs and Child Cognition at 5 Years Old” J Nutr. 2021 Apr 8;151(4)
  53. Schwinger C, Sharma S, Chandyo RK, Hysing M, Kvestad I, Ulak M et al. “
    Cobalamin and folate status in women during early pregnancy in Bhaktapur, Nepal”. J Nutr Sci. 2021 Aug
  54. Richard SA, McCormick BJJ, Murray-Kolb LE, Patil CL, Chandyo RK, Mahopo C, et al. “
    Characteristics associated with the transition to partial breastfeeding prior to 6 months of age: Data from seven sites in a birth cohort study”. Matern Child Nutr. 2021 Jul;17(3)